INDIA-FIRST · PRIORITY PROGRAMMES

Ten disease areas worth
earning the right to pursue.

Selected with a composite lens of India disease burden, unmet need, demand and fit with BayesPharma’s discovery system. These are research priorities at target-selection stage—not clinical assets, valuation forecasts or guarantees of profitability.

India burdenUnmet needDemandScientific fitEvidence discipline
01
METABOLIC

Type 2 diabetes + obesity

High chronic disease burden and commercial relevance with multiple opportunities for differentiated small-molecule and incretin-pathway discovery.

DISCOVERY FOCUSIncretin signalling · insulin sensitization · oral differentiation
TARGET HYPOTHESES · PRE-VALIDATIONGLP-1R · GIPR · AMPK
02
CARDIOMETABOLIC

Hypertension + heart failure + dyslipidemia

A broad chronic-care opportunity where resistant hypertension, HFpEF biology and residual lipid risk create multiple hypothesis spaces.

DISCOVERY FOCUSResistant hypertension · HFpEF · residual lipid risk
TARGET HYPOTHESES · PRE-VALIDATIONCYP11B2 · NLRP3 · lipid pathways
03
ONCOLOGY · INDIA-FIRST

Oral & head-and-neck cancer

An India-relevant oncology priority with room for precision small molecules, resistance-aware combinations and biomarker-linked design.

DISCOVERY FOCUSPrecision small molecules · resistance biology · combinations
TARGET HYPOTHESES · PRE-VALIDATIONEGFR · PI3K/AKT · DDR nodes
04
ONCOLOGY

Breast cancer / triple-negative disease

A specialty programme space focused on aggressive or resistant disease and biomarker-linked synthetic-lethality strategies.

DISCOVERY FOCUSTNBC vulnerabilities · resistance · biomarkers
TARGET HYPOTHESES · PRE-VALIDATIONPI3K/AKT · PARP/DDR · synthetic lethality
05
AMR · INDIA-FIRST

Carbapenem-resistant Gram-negative infections

A high-urgency hospital and public-health priority focused on resistant Enterobacterales and Acinetobacter, where new outer-membrane transport mechanisms may bypass legacy antibiotic cross-resistance.

DISCOVERY FOCUSLol lipoprotein transport · Gram-negative penetration · resistance-aware design
TARGET HYPOTHESES · PRE-VALIDATIONLolCDE / LolDF lead hypothesis · Lpt/Bam envelope transport backup
06
RENAL

Chronic kidney disease + diabetic kidney disease

A growing chronic-care area linked tightly to diabetes and hypertension, with opportunities around inflammation, fibrosis and cardiorenal protection.

DISCOVERY FOCUSInflammation · fibrosis · cardiorenal protection
TARGET HYPOTHESES · PRE-VALIDATIONNLRP3 · MR signalling · fibrotic pathways
07
RESPIRATORY

COPD + severe asthma

Chronic respiratory disease creates a large India-relevant need for better exacerbation prevention and differentiated add-on therapies.

DISCOVERY FOCUSAirway inflammation · exacerbation prevention · oral add-on
TARGET HYPOTHESES · PRE-VALIDATIONPDE4B · IL-33/ST2 · inflammatory signalling
08
METABOLIC LIVER

MASH / metabolic liver disease

Metabolic liver disease follows the same obesity, diabetes and dyslipidemia wave and offers multi-parameter opportunities around fat, inflammation and fibrosis.

DISCOVERY FOCUSLiver fat · inflammation · fibrosis regression
TARGET HYPOTHESES · PRE-VALIDATIONTHRβ · FXR · lipid metabolism
09
INFECTIOUS DISEASE

MDR / RR tuberculosis

A critical India-first and global-access challenge where new oral mechanisms and resistance-robust regimens remain strategically important.

DISCOVERY FOCUSNovel mechanisms · shorter oral regimens · resistance robustness
TARGET HYPOTHESES · PRE-VALIDATIONDprE1 · MmpL3 · QcrB
10
VECTOR-BORNE ANTIVIRAL

Dengue antivirals

An India-relevant programme space focused on direct-acting antivirals, pan-serotype activity and early outpatient treatment hypotheses.

DISCOVERY FOCUSDirect-acting antivirals · pan-serotype activity · outpatient use
TARGET HYPOTHESES · PRE-VALIDATIONNS2B/NS3 · NS5 polymerase · NS5 methyltransferase